In cystic fibrosis (CF), defective biogenesis and activity of the cystic fibrosis transmembrane conductance regulator (CFTR) leads to airway dehydration and impaired mucociliary clearance, resulting in chronic airway infection and inflammation.The most common CFTR mutation, F508del, results in a processing defect in which the protein is retained in

Pendahuluan: Daun lengkeng (Dimocarpus longan) adalah salah satu tanaman berasal dari daerah subtropis, dan mampu tumbuh dan berproduksi dengan baik di daerah tropis Indonesia termasuk Provinsi Bengkulu dan berkhasiat sebagai antioksidan.Tujuan: untuk membuat sediaan lotion dari ekstrak daun lengkeng dengan konsentrasi 0,5%, 1,5% dan 2,5%.Metode: P

Polycystic liver disease rarely occurs in isolation as part of autosomal dominant polycystic liver disease, but more commonly, it exists as an extra-renal manifestation of autosomal dominant polycystic kidney disease.The pathogenesis of polycystic liver disease involves defects in the primary cilium of the cholangiocyte, with genetic mutations that

It is widely recognized in science, policy, and practice that protected areas (PAs) that are equitably and effectively managed are essential for halting biodiversity loss.However, our understanding of the relationships between management effectiveness and equity remains weak.Here, we investigate potential synergies and ASHWAGANDHA trade-offs betwee